Tuberculin skin reactivity after neonatal BCG vaccination in preterm infants in Minas Gerais, Brazil, 2001-2002.
نویسندگان
چکیده
OBJECTIVES The efficacy of BCG vaccination in preterm babies is unknown, and available data on conversion rates to tuberculin in this age group are scarce and controversial. This study assessed the tuberculin response in preterm infants after BCG vaccination. METHODS This randomized cohort study was carried out at the Neonatal Department, University Hospital, Federal University of Minas Gerais in Brazil during 2001 and 2002. The BCG vaccine was administered at birth to 65 full-term (control) and 40 preterm newborns. All of them were tested with 5 tuberculin units of purified protein derivative-S approximately 3 months after vaccination. RESULTS A typical BCG scar was verified in 96.9% of the control group and in 90.0% of the preterm infants (P = 0.19). Indurations > 5 mm in diameter were recorded in 87.7% of the full-term and 67.5% of the preterm infants (P = 0.02). Indurations > 10 mm were recorded in 70.8% of the full-term and 42.5% of the preterm infants (P = 0.007). For indurations > 5 mm the upper and the lower limits of the 95% confidence interval for the difference between proportions were 8.5% to 31.8%, and for indurations > 10 mm these limits were 18.0% to 38.4%. No adverse reactions were observed in the study population. CONCLUSION BCG vaccination could be recommended for preterm infants upon discharge from the neonatal unit to reduce morbidity and mortality in infants at risk for tuberculous infection, and to increase BCG vaccination coverage rates, especially in countries with high prevalence rates of tuberculosis.
منابع مشابه
Tuberculin skin reactivity four years after neonatal BCG vaccination.
Two hundred and sixty one of 279 (93.5%) children known to be tuberculin positive shortly after receiving their neonatal BCG vaccination were still tuberculin positive at age 4 years. The results confirm the continuing effectiveness of neonatal BCG at 4 years.
متن کاملTuberculin response in preterm infants after BCG vaccination at birth.
A total of 101 preterm infants between 26 and 37 weeks' gestation who received BCG vaccination at birth were evaluated between two and four months after vaccination. Altogether 32% of these infants had no visible BCG scar. All infants were then tested with tuberculin purified protein derivative (PPD) but only 70 returned for the test to be read 48-72 hours later. The test was negative in 22 (31...
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1 Medical Research Council Tuberculosis and Chest Diseases Unit. Tuberculosis in children: a national survey of notifications in England and Wales. Arch Dis Child 1988;63:266-76. 2 Research Committee of the British Thoracic Association. Effectiveness of BCG vaccination in Great Britain in 1978. Br3' Dis Chest 1980;74:215-27. 3 Sutherland I, Springett VH. Effectiveness of BCG vaccination in Engl...
متن کاملTuberculin reactivity in a population of schoolchildren with high BCG vaccination coverage.
OBJECTIVE To investigate the influence of BCG vaccination or revaccination on tuberculin skin test reactivity, in order to guide the correct interpretation of this test in a setting of high neonatal BCG vaccination coverage and an increasing BCG revaccination coverage at school age. METHODS We conducted tuberculin skin testing and BCG scar reading in 1 148 children aged 7-14 years old in the ...
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ورودعنوان ژورنال:
- Revista panamericana de salud publica = Pan American journal of public health
دوره 19 6 شماره
صفحات -
تاریخ انتشار 2006